Innovative solutions for regenerative medicine applications with clinical relevance

Guest editor: Roberto Gramignoli, Karolinska Institutet, Stockholm, Sweden


This third decade of the new millennium has forced all of us to face urgent needs in clinical practice, but it may optimistically also turn into a golden time in regenerative medicine. Researchers have been ignited to explore and translate innovative solutions in healthcare and biotech enterprises. Regenerative medicine is a fast-growing branch of translational research, with the purpose of restoring the structure and function of damaged tissues or organs, generating new technology for biotherapeutics and bio-engineered approaches. A multitude of advanced therapy medicinal products proposed during recent years has been slowly but dramatically transforming the health care system, harnessing the power of repairing, replacing, restoring, and regenerating human organs and tissues affected by various degenerative disorders and diseases.
In somatic tissues as well as perinatal tissues, different types of stem and progenitor cells have been identified, mainly involved in maintaining homeostasis and supporting innate capacity to regenerate. Such (pluri/multi) potent cells have been used in both autologous and allogeneic clinic settings. Scientists and clinical innovators in the field of regenerative medicine and tissue engineering are nowadays exploiting such multi-potency as well as immunomodulatory properties characteristic in such stem and progenitor cells to restore and maintain normal function in diseased and injured tissues.
This Special Issue seeks research papers on various aspects related to the emerging field of precision medicine, and clinical research, covering different aspects of the basics of translational research, regenerative medicine, and personalized treatments.

Keywords: regenerative medicine; ATMP; immunomodulatory; transplantation; bioengineering; clinical research; cell therapy; personalized treatments

Submission deadline: November 30, 2023

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Hemolytic disease of the fetus and newborn

Guest editors: Enrico Lopriore, Department of Neonatology, Leiden University Medical Centre, the Netherlands; E.J.T. (Joanne) Verweij, Department of Obstetrics, Leiden University Medical Centre, the Netherlands


Hemolytic disease of the fetus/newborn (HDFN) results from maternal alloimmunization to red cell antigens, for which mother and fetus are incompatible. In HDFN, maternal immunoglobulin (IgG) antibodies cross the placenta causing destruction of fetal red blood cells and fetal anemia. Antenatal treatment with intrauterine transfusion may be required in case of severe fetal anemia or fetal hydrops. Postnatal management is based on intensive phototherapy and exchange transfusion in case of excessive hyperbilirubinemia. Unconjugated bilirubin may pass through the blood-brain barrier and lead to permanent brain damage due to kernicterus. During the last decades a significant evolution in treatment strategies has occurred and new management options have led to a remarkable decrease in perinatal mortality and morbidity. Nevertheless, several questions remain unanswered and there is still room for improvement. This special edition will include important reviews and articles focusing on pathogenesis, diagnosis, management and outcome in HDFN, and also address future perspectives.

Keywords: hemolytic disease of the foetus and newborn; red blood cell alloimmunization, rhesus hemolytic disease

Submission deadline: December 31, 2023

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Otolaryngology: clinical outcomes, management, and challenges

Guest editor: Dr. Ignazio La Mantia, University of Catania, Italy


Otorhinolaryngology was established in the late 19th and early 20th century as a unified specialization that deals with medical conditions of the head and neck. It has seen dramatic development in the past decades along with technical innovations.

This Special Issue aims to offer readers and colleagues the latest trends, modern diagnostic tools, treatment modalities, and beyond in the otorhinolaryngologic fields. With the perspective of precision medicine and a multidisciplinary approach, this Special Issue aims to describe not only the challenges in otorhinolaryngological diagnostics and surgical managements but also to provide useful models and tools for personalized therapeutic strategies in clinical practice.

Given the very broad yet very specialized nature of otorhinolaryngology, we invite researchers and experts from all subspeciliazations to contribute to this special issue.

Keywords: otolaryngology; endoscopy; otorinolaryngologists; otoneurosurgery; rhinology; laryngological; multidisciplinary

Submission deadline: December 31, 2023

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Regenerative medicine in head and neck: clinical and basic science perspectives

Guest editor: Prof. Petros D. Karkos,  Aristotle University of Thessaloniki; 1st Department of Otolaryngology, AHEPA University Hospital, Thessaloniki, Greece

Regenerative medicine (RM) has been rapidly evolving in many directions and fields of medicine. Tissue engineering gives the opportunity to rectify abnormalities by using scaffolds that simulate the normal structure and function of many organs and tissues. The field of Head and Neck is large including paramount functions such as breathing, hearing, balance, voice and swallowing, facial expressing and aesthetics. The diversity of the cells and tissues concerning all those vital functions makes RM very challenging in the field of otorhinolaryngology, facial plastics, dermatology and maxillofacial surgery. 

We invite authors from all the specialties above to submit to this special issue.

Submission deadline: October 31, 2023

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