Jimmy Menis*, Marie Doussiere, Estelle Touboul, Vincent Barbier, Jean-Marc Sobhy-Danial, Patrice Fardellone, Mathurin Fumery, Guillaume Chaby, Vincent Goëb
Menis et al. J Clin Transl Res 2023; 9(2):1
Published online: February 6, 2023
Background and aim: Psoriatic arthritis (PsA) is a polymorphic disease associated with numerous comorbidities. The objective of this study was to describe the main clinico-biological and imaging characteristics of a population of PsA and to extract any disparities between men and women.
Methods: A total of 132 patients in the rheumatology department of Amiens University Hospital with a confirmed diagnosis of PsA according to the CASPAR criteria were included over a period of 4 months. All data were collected retrospectively in this observational and single-center study.
Results: The sex ratio was 1 and the average age at inclusion was 54.9 years. Peripheral PsA was the predominant clinical form. Axial PsA represented 12.1% of cases. Enthesitis was noted in 52.3% of cases while dactylitis was identified in 29.5% of cases. Moreover, 12.1% had a joint symptomatology preceding the appearance of cutaneous signs. HLA-B*27 positivity was found in 33.3% of cases. Chronic hyperuricemia accounted for 10% of our population. Sacroiliitis was observed in 41% of cases. The disparities between men and women are multiple and consistent with the literature: polyarticular form, enthesitis, obesity, more intensive prescription of s-DMARDs, and b-DMARDs are more associated with the female population. Oligoarticular form, psoriatic nail dystrophy, radiological axial involvement and chronic hyperuricemia are more encountered in the male population.
Conclusions: Our study found a very heterogeneous disease, with marked differences between men and women. Peripheral PsA remains predominant but the search for associated axial involvement, which is probably underestimated, seems essential.
Relevance for Patients: This work studied the main characteristics of patients with PsA followed in real life, in a regional university reference center. We have highlighted a very heterogeneous disease as well as some gender disparities, not well described in the literature, which should be taken into account in order to optimize therapeutic management.
1. Department of Rheumatology, Amiens University Hospital, 80000 Amiens, France
2. Department of Pediatric Physical Medicine and Rehabilitation Center, Amiens University Hospital, 80000 Amiens, France
3. Department of Gastroenterology, Amiens University Hospital, 80000 Amiens, France
4. Department of Dermatology, Amiens University Hospital, 80000 Amiens, France
Department of Rheumatology, Amiens University Hospital, 80000 Amiens, France.
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Chemistry, Utrecht University, Utrecht, the Netherlands
Department of Pathology, Erasmus Medical Center, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China
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