B. Goksoy, Y. Tosun, M. Ozgur Gunay

Goksoy et al. J Clin Transl Res 2022; 8(4):2

Published online: June 17, 2022


Background: Large cell neuroendocrine carcinomas (LCNEC) of the colon are an extremely rare and aggressive type of colorectal cancer. While multifocality is more frequently seen in small intestine NECs, no cases of multifocal NEC of the colon have been reported before.
Aim: A 69-year-old male patient presented with abdominal pain. Colonoscopy revealed a necrotic-polypoid mass in the sigmoid colon and the biopsy result was reported as malignant epithelial tumor. Laparoscopic anterior resection was performed with the preliminary diagnosis of colon adenocarcinoma. Histopathological examination revealed three polypoid tumors, the largest of which was 4 cm, in the sigmoid colon. Immunohistochemical examination showed positivity for synaptophysin, chromogranin and CDX2. High Ki67 proliferation index, high mitosis and widespread p53 expression were observed in all tumors. With these findings, a diagnosis of multifocal large cell NEC was made. To our knowledge, this is the first report describing a case of multifocal large cell NEC of the colon.
Relevance for Patients: LCNECs of the colon are very aggressive. Here, we report for the first time a case of multifocal LCNEC. In a short period of 1 month after the surgery, new widespread metastases were detected in the liver. Therefore, these tumors should be followed more closely than usual for early treatment.


DOI: http://dx.doi.org/10.18053/jctres.08.202204.002

Author affilation

1. Department of General Surgery, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Turkey
2. Department of Pathology, Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital, İstanbul, Turkey

*Corresponding author
B. Goksoy
Abdurrahmangazi mah. Sevenler Cad. Sinpaş Ege boyu Sitesi. M2 Blok daire: 5. Sancaktepe, Istanbul, Turkey
Telephone: +90 5349530112
Fax: +90 216 3033333
E-mail: beslengoksoy@gmail.com

Handling editor:
Michal Heger
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China


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