Hanadi Abdelgadir Ahmed Sourg, Adil Ballal Mohammed Ahmed, Ramaze Farouke Elhakeem, Mohamed Faisal Lutfi
Abdelgadir et al., J Clin Transl Res 2020; 6(1): 5
Published online: July 13, 2020
Background: Pathophysiology of hypertension and bronchial asthma (BA) share many similarities, especially those related to the metabolic syndrome (MS).
Aim In this study, the indicators of the MS were evaluated in normoglycemic normotensive asthmatic patients in order to clarify if the components of the MS can still interact to increase the risk of BA, provided that blood pressure and glucose level are kept within the normal physiological ranges.
Methods: Body mass index (BMI), waist circumference (WC), mean arterial blood pressure (MABP), fasting blood glucose (FBG) and insulin (FBI) levels, the quantitative insulin sensitivity check index (QUICKI), serum lipid profile and spirometric measurements were all compared between 120 asthmatic patients and 59 non–asthmatic subjects. Cigarette smoking, pregnancy, age below 20 years or above 40 years, diabetes mellitus and hypertension and other chronic diseases were excluded from all studied groups.
Results: Asthmatic patients demonstrated higher WC (median (25th –75th interquartile) = 88.50 (78.00-101.75), FBI (19.98 (11.12- 40.14), triglyceride level (109.5 (76.50- 134.0)) compared with non-asthmatic subjects (81.00 (72.00-92.00), 13.78 (8.84- 30.24), 89.00 (64.25- 104), P < 0.05). QUICKI and MABP were lower in asthmatic patients (0.310 (0.283- 0.338), 86.66 (83.33- 93.33)) compared with non-asthmatic subjects (0.320 (0.297- 0.353), 93.33 (83.33- 93.33)), P < 0.05). BMI, FBG, LDL, HDL, and total cholesterol levels were comparable in the studied groups.
Conclusions: The present finding gives further evidence for higher WC, FBI, triglyceride level and insulin resistance in in normotensive, normoglycemic asthmatic patients compared to healthy controls.
Relevance for patients: The findings of this study suggested that abdominal obesity, hypertriglyceridemia, hyperinsulinemia and insulin resistance may still be interacting and hence increase the risk of BA in normotensive, normoglycemic subjects.
1 Faculty of Medicine, University of Khartoum, Khartoum, Sudan
2 Faculty of Medicine, Al Neelain University, Khartoum, Sudan
3 King Saud bin Abdulaziz University for Health Sciences, Riyadh, KSA
4 College of Medicine, Qassim University, Qassim, KSA
5 Nile College of Medicine Khartoum, Sudan
* Corresponding author
Mohamed Faisal Lutfi
Department of Physiology,
Nile College, Khartoum, Sudan
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China
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