Tatiane Gomes Teixeira, Dahan da Cunha Nascimento, Ramires Alsamir Tibana, Nuno Manuel Frade de
Sousa, Vinicius Carolino de Souza, Jeeser Alves de Almeida, Amilton Vieira, Octavio Luiz Franco,
Guilherme Borges Pereira, Jonato Prestes
Teixeira et al., J Clin Transl Res 2016; 2(2): 70-77
Published online: 19 June, 2016
Abstract
Background and Aim: The present study examines nitrite concentration responses following eccentric resistance exercise (ERE) in elderly obese women. The existence of high (HR) and low responders (LR) for nitrite and the possible differences with respect to creatine kinase (CK) response, metabolic and body composition variables were also investigated.
Methods: Forty-nine elderly obese women completed an ERE session utilizing knee extensor exercise. LR for serum nitrite were defined as a ∆nitrite ≤ 20th percentile or 24.1 µM and HR as a ∆ nitrite > 20th percentile.
Results: Ten subjects were classified as LR and the remaining as HR (n = 39). The HR group displayed greater nitrite concentration at 0 h, 3 h, 24 h and 48 h following the ERE as compared with the LR (p < 0.05), and CK increased after 24 h and 48 h only for the HR group following the ERE (p < 0.05). Peak nitrite concentration was higher in the HR group versus the LR group (p < 0.05), while there was no difference between groups for pre-exercise nitrite values. The LR group displayed higher (p < 0.05) body fat, cholesterol, LDL and lower upper limb fat-free mass as compared with the HR group. The LR had lower (p < 0.05) upper limb fat-free mass than the HR group.
Conclusions: Elderly obese women classified as HR displayed higher nitrite responses to ERE. Thus, re-searchers should be aware of the presence of different responsiveness of nitrite to acute exercise to avoid misinterpretation of data and to identify the higher cardiovascular risk factor of those classified as LR.
Relevance for patients: The elevated NO up to 48 h following an ERE session may suggest an important protective cardiovascular effect. The higher body fat, cholesterol, LDL and lower upper limb fat-free mass in the LR group might represent a deleterious effect of lower serum levels of nitrite.
DOI: http://dx.doi.org/10.18053/jctres.02.201602.005
Author affiliation
1 Catholic University of Brasilia, Graduation Program on Physical Education, Brasilia, Brazil
2 Laboratory of Exercise Physiology, Faculty Estacio of Vitoria, ES, Brazil
3 University of Brasilia, Brasilia, Brazil
4 Physical Education Department, Federal University of Mato Grosso of South, Brazil
5 Graduation Program on Biotechnology and Genomic Sciences, Catholic University of Brasilia, Brazil
6 Graduation Program in Gerontology, Catholic University of Brasilia, Brasilia, Brazil
*Corresponding author:
Jonato Prestes
Catholic University of Brasilia - Q.S. 07, Lote 01, EPTC – Bloco G. Zip code: 71966-700 – Taguatinga – Federal District, Brasilia, Brazil
Email: jonatop@gmail.com
Handling editor:
Michal Heger
Rowan van Golen
Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, the Netherlands
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