This study was performed to optimize existing heart decellularization protocols and compare current methods through retrograde aortic perfusion via aortic cannulation of a whole porcine heart.Read more
Idiosyncratic drug reactions (IDRs) continue to be an important issue. Specifically, idiosyncratic drug-induced liver injury (IDILI) is the most likely IDR to lead to drug withdrawal, and it accounts for a significant portion of all cases of acute liver failure. In addition, IDRs are unpredictable and their mechanisms are not well understood.Read more
This review focuses on the mechanisms behind APAP-induced hepatotoxicity and the relevance of these to the human pathophysiology. Current investigations on various biomarkers which may be useful in clinical management of APAP overdose patients are also discussed.Read more
The goal of this article is to review sterile inflammatory liver injury using both a basic approach to what constitutes the inflammatory injury, and through examination of current models of liver injury and inflammation. This information will be tied to human patient conditions when appropriate.Read more
The role of connexin signaling in drug-induced hepatotoxicity may be of high clinical relevance, as it offers perspectives for the therapeutic treatment of such insults by interfering with connexin channel opening.Read more
Obesity is often associated with nonalcoholic fatty liver disease (NAFLD). This study discusses NAFLD as risk factor for drug-induced hepatotoxicity.Read more
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All papers of the special issue "Drug-induced Hepatotoxicity" are now published as Epubs ahead of print. This special issue is composed of 6 review articles authored by Alastair Mak and Jack Uetrecht (University of Toronto, Canada), Anup Ramachandran and Hartmut Jaeschke (University of Kansas Medical Center, USA), Benjamin Woolbright and Hartmut Jaeschke (University of Kansas Medical Center, USA), Michaël Maes and Mathieu Vinken (Vrije Universiteit Brussel, Belgium), Daniel Antoine and colleagues (University of Liverpool, United Kingdom), and Bernard Fromenty and colleagues ( Université de Rennes 1, France). Read the articles.
The editors, Prof. Hartmut Jaeschke and Dr. Anup Ramachandran, explain the structure, the content, and the value of the special issue in the preface. Read the article and the biographies of the editors.