Zhenhua Li#, Yongliang Li#, Yue Wu#, Mingyan Li, Zhaobin Yan, Shanwen Nie, Zhitao Liang, Bo Li, Peiwen Zhu, Peilin Cui, Qinsheng Zhang*
Li et al. J Clin Transl Res 2022; 8(2):4
Published online: March 1, 2022
Abstract
Background and aim: A technique of endoscopic tightening of the cardia mucosa for the treatment of gastroesophageal reflux disease (GERD) was developed and its clinical efficacy was observed.
Methods: 120 patients with GERD who underwent endoscopic tightening surgery from December 2017 to December 2019 were included in this study. Gastroesophageal reflux score (GERD Q) and constitution type of patients were evaluated preoperatively and at 1 month, 3months, 6 months and 1 year after surgery. In addition, effectiveness and side effects of the procedure were graded based on gastroesophageal flap valve (GEFV) function.
Results: GERDQ score of 1 month, 3months, 6 months and 1 year after surgery were significantly decreased (P<0.01) compared with preoperative score. There were no significant differences between GERDQ of 1 month, 3months, 6 months and 1 year after surgery. The surgery proves to be effective in all GEFV grades, especially in Hill-III.
Conclusion: Endoscopic tightening is an effective method for the treatment of patients with GERD, especially of Hill-III patients. Attention should be paid to cardia width, ligation ring depth and ring number during operation.
Relevance for patients: ETCM is a safe endoscopic procedure with minimal trauma, which has been proved effective for patients who are diagnosed with GRED.
DOI: http://dx.doi.org/10.18053/jctres.08.202202.004
Author affiliation
1. Department of Hepatobiliary and Spleen and Gastroenterology, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China
2. International Medical Services (IMS), Beijing Tiantan Hospital of Capital Medical University, Beijing, China
#These authors contributed equally to this work.
*Corresponding Author
Qinsheng Zhang
Department of Hepatobiliary and Spleen and Gastroenterology, Henan Provincial Hospital of Traditional Chinese Medicine, 6 Dongfeng Road, Jinshui District, Zhengzhou 450002, Henan Province, China.
Tel: +86-13653711185
Fax: +86-371-53312102
Email: 80792825@qq.com
Handling editor:
Michal Heger
Department of Pharmaceutics, Utrecht University, the Netherlands
Department of Pharmaceutics, Jiaxing University Medical College, Zhejiang, China
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